get behind and slightly below and shoot the tips of the wings. i typically shoot the rear gunner first though.
In WWII, Japanese planes ended up CRASHING INTO THE B-29! One time a Superfort was attacked was attacked by 3 Japanese planes (by attacked I mean "was kamikazed by")
I consider myself a pretty good bomber-hunter, but my poor 109 rarely, if ever, comes back from a mission against them without being splattered with her own oil; it's my own fault for focusing too much on the target and not enough on what the target is sending back my way, impact sounds be damned.
That aside, the best way to bring down any large multi-engine bomber is to concentrate your fire on the wings; if you hit the engines, great, and if not, you may have seriously damaged their control surfaces and if you're even luckier you might just cut a wing off. Granted, this takes a great deal of fire without cannons, which I hate to fly without the Mk108 pods...